Abstract:

The review of modern views on obesity genesis is presented in this paper. Possibility of using suggested approaches in development of targeted anti-age programs are shown. Today adipose tissue is qualified as powerful endocrine and immune organ, which regulation of activity is carried out with neuropeptids involving. There is an imbalance in production of pro- and anti-inflammatory agents at obesity that made adipose tissue an environment for chronic immune inflammation process. It is associated pathogenetically with insulin resistance, metabolic syndrome, cardiovascular and other pathology. Signaling molecule levels and dynamics definition at the patients with obesity and multisystem somatic pathology can be viewed as the way of special targeted therapy ordering in treatment of this multimorbid pathology.

Keywords: obesity, signaling molecule, neuroimmunoendocrinology, targeted therapy