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Ãëàâíàÿ / Íîìåðà æóðíàëîâ /¹ 1, 2013

Biological Sciences
POSSIBLE ANTI FLU EFFECTIVENESS OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS
Bessarabov V. I. 1, Zderko N. P. 2

1. Kyiv National University of Technologies and Design, Industrial Pharmacy Department, Kyiv, Ukraine
2. Kyiv National University of Technologies and Design, Industrial Pharmacy Department, Kyiv, Ukraine

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In the work the results of the first stage of the purposeful search in silico of possible anti flu effectiveness of some low toxic active pharmaceutical ingredients are represented. For virtual screening the service of Prediction of Activity Spectra for Substances (PASS) was used. It shows that according to the results of virtual screening of 60 active pharmaceutical ingredients potentially high antivirus activeness can reveal: γ-aminobutanoic acid (GABA), valeric acid, bornyl valerate, bornyl acetate, silandrin, dihydroquercetin (taxifolin), hesperidine, tiliroside, astragalin, hyperoside, baicalin, scutellarin, glucuronic acid. Most of these substances are in the extracts of medicinal herbs and they belong to flavonoids.

Keywords: in silico, virtual screening, viral infections, elderly people, vegetable extracts, flavonoids, active pharmaceutical ingredients, antivirus activeness

Reference

Bessarabov V. I. 1, Zderko N. P. 2 POSSIBLE ANTI FLU EFFECTIVENESS OF SOME ACTIVE PHARMACEUTICAL INGREDIENTS // ÃÅÐÎÍÒÎËÎÃÈß. – 2013. – ¹ 1;
URL: gerontology.esrae.ru/1-5 (Date Access: 22.11.2024).

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