Abstract:

Polymorbidity problem - one of the most urgent problems of modern clinical medicine. With age, there is a "accumulation" of chronic diseases, there is a multiplicity of pathological processes. Start of diseases forming polymorbidity syndrome usually falls on the middle age. Elderly - a period of clinical manifestations of complex diseases. In recent years, particular attention is paid to participate in pathological processes neyroimmunoendokrinnoy system. Objective: to study features of cytokine status in the parameter "tumor necrosis factor alpha ´(TNF-a) in older women and to determine their impact on the development polymorbidity pathology. Based on this work we can say that menopause is correlated with the pathological imbalance of TNF-a. This predisposes to the formation of arterial hypertension, which in turn exacerbates the cytokine imbalance, especially against the background of the formation of arterial hypertension (AH) coronary artery disease (CAD).

Keywords: cytokinemia, polymorbidity, hypertension, advanced age